ZIA BC 011222 (ZIA) | |||
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Title | CNS sirtuins in radiation-induced vascular permeability and neurodegeneration | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Smart, DeeDee | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $242,754 | Project Dates | 10/01/2008 - N/A |
Fiscal Year | 2010 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) Chemotherapy (75.0%) |
Brain (100.0%) Nervous System (100.0%) |
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Research Type | |||
Localized Therapies - Discovery and Development Development and Characterization of Model Systems |
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Abstract | |||
This project was begun on August 2, 2009. There is currently not adequate data acquired in the past month to be able to provide a comprehensive Project Summary Statement. Nevertheless, we have currently data identifying sirtuins and potential interacting proteins in the central nervous system. We also have sirtuin 2 knockout and wild-type mice which have been re-derived and will be utilized in cerebral irradiation experiments, and will be used as a model of radiation-induced neurocognitive changes and neuronal degeneration. |